报告题目：Interlocked feedback loops balance the adaptive immune response

主 讲 人：杨凌  苏州大学教授

时 间：4月14日9:00

地 点：腾讯会议 ID：916-396-924  密 码：123456

主办单位：数学与统计学院

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报告摘要：Adaptive immune responses can be activated by harmful stimuli. Upon activation, a cascade of biochemical events ensues the proliferation and the differentiation of T cells, which can remove the stimuli and undergo cell death to maintain immune cell homeostasis. However, normal immune processes can be disrupted by certain dysregulations, leading to pathological responses, such as cytokine storms and immune escape. In this paper, a qualitative mathematical model, composed of key feedback loops within the immune system, was developed to study the dynamics of various response behaviors. First, simulation results of the model well reproduce the results of several immune response processes, particularly pathological immune responses. Next, we demonstrated how the interaction of positive and negative feedback loops leads to irreversible bistable, reversible bistable and monostable, which characterize different immune response processes: cytokine storm, normal immune response, immune escape. The stability analyses suggest that the switch-like behavior is the basis of rapid activation of the immune system, and a balance between positive and negative regulation loops is necessary to prevent pathological responses. Furthermore, we have shown how the treatment moves the system back to a healthy state from the pathological immune response. The bistable mechanism that revealed in this work is helpful to understand the dynamics of different immune response processes.

主讲人简介：杨凌，苏州大学数学学院教授，博士生导师。长期从事生物系统的数学模型及数值计算方面工作。担任国家重点研发计划重点专项课题（建立小鼠发育代谢表型库----样本库和表型分析大数据数据库建设与质控，774万，在研）负责人，主持（在研或结项）四个国家自然科学基金面上项目。 在Biophysical Journal(Cell子刊)，Cell Death and Differentiation (Nature子刊)，Journal of Biological Chemistry, Physical Review Letters (SCI—区)等杂志上发表论文30余篇。